Études et publications

EPLS a réalisé de nombreuses études sous l’égide du Ministère des Affaires Etrangères Français, de la Communauté Européenne, et de l’Organisation Mondiale de la Santé (OMS). Depuis 1992, EPLS a réalisé plus de 50 programmes de recherche appliquée dans la vallée du fleuve, dont les résultats ont donné lieu à près de 100 publications dans des revues scientifiques et médicales internationales à comité de lecture.

Publications

Seroprevalence of pertussis in Senegal: a prospective study

Gaayeb L, Sarr JB, Ndiath MO, Hanon JB, Debrie AS, Seck M, Schacht AM, Remoué F, Hermann E, Riveau G.

PLoS One, 2012, 7(10):e48684 (PMID : 23119090)

The purpose of this longitudinal study was to investigate seroprevalence of Pertussis (also known as whooping cough) in children from Northern Senegal, and to gain some insight on the evolution of these children’s humoral response towards pertussis antigens over 18 months. This work has confirmed the age-dependent response profile to whooping cough previously observed in industrialized countries. Moreover, our study has shed a light over the circulation of Bordetella pertussis in this sub-Saharan location. Finally, we have demonstrated that while some of the studied villages were endemic for B. pertussis, an outbreak has occurred in another village during the course of our study. We are convinced that assessing the seroprevalence of Pertussis in Northern Senegal is essential in the frame of monitoring the impact of the Expanded Program for Immunization from the World Health Organization on immunity to this vaccine-preventable respiratory disease in this particular setting.

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Immunoglobulin G antibody profiles against Anopheles salivary proteins in domestic animals in Senegal

Boulanger D, Doucoure S, Grout L, Ngom A, Rogerie F, Cornelie S, Sokhna C, Mouchet F, Riveau G, Simondon F, Remoue F

Journal of Medical Entomology, 2011, May 48(3):691-3 (PMID : 21661332)

Although domestic animals may not be permissive for Plasmodium, they could nevertheless play a role in the epidemiology of malaria by attracting Anopheles away from humans. To investigate interactions between domestic animals and mosquitoes, we assayed immunoglobulin G (IgG) antibodies directed against the salivary proteins of Anopheles gambiae in domestic animals living in Senegalese villages where malaria is endemic.

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Assessment of exposure to Plasmodium falciparum transmission in a low endemicity area by using multiplex fluorescent microsphere-based serological assays.

Sarr JB, Orlandi-Pradines E, Fortin S, Sow C, Cornelie S, Rogerie F, Guindo S, Konate L, Fusaï T, Riveau G, Rogier C, Remoue F.

Parasites and Vectors, 2011, Nov 7;4:212. (PMID : 22059951)

The evaluation of malaria transmission intensity is a crucial indicator for estimating the burden of malarial disease. In this respect, entomological and parasitological methods present limitations, especially in low transmission areas. The present study used a sensitive multiplex assay to assess the exposure to Plasmodium falciparum infection in children living in an area of low endemicity.

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